Chemical space guided discovery of antimicrobial bridged bicyclic peptides against Pseudomonas aeruginosa and its biofilms† †Electronic supplementary information (ESI) available: Characterization of all compounds, crystallography tables, and characterization of all compounds. See DOI: 10.1039/c7sc01314k Click here for additional data file.
نویسندگان
چکیده
Chemical Space Guided Discovery of Antimicrobial Bridged Bicyclic Peptides Against Pseudomonas aeruginosa and its Biofilms Ivan Di Bonaventura, Xian Jin, Ricardo Visini, Daniel Probst, Sacha Javor, Bee-Ha Gan, Gaëlle Michaud, Antonino Natalello, Silvia Maria Doglia, Thilo Köhler, Christian van Delden, Achim Stocker, Tamis Darbre and Jean-Louis Reymond* Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, 3012 Berne Switzerland; jean-louis.reymond@dcb.unibe.ch
منابع مشابه
Chemical space guided discovery of antimicrobial bridged bicyclic peptides against Pseudomonas aeruginosa and its biofilms.
Herein we report the discovery of antimicrobial bridged bicyclic peptides (AMBPs) active against Pseudomonas aeruginosa, a highly problematic Gram negative bacterium in the hospital environment. Two of these AMBPs show strong biofilm inhibition and dispersal activity and enhance the activity of polymyxin, currently a last resort antibiotic against which resistance is emerging. To discover our A...
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2017